Retrieved sources were further explored applying both the snowball approach Table 1. Cystatin C (CysC) reference values as reported in literature in full term. A cistatina C tem sido proposta com um marcador alternativo da filtração em relação à creatinina. O presente estudo foi conduzido com o objetivo de avaliar o . Request PDF on ResearchGate | La cistatina C aporta más información que otros parámetros de función renal en la estratificación del riesgo.

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Cystatin C can be affected by nonrenal factors: Clin Chem Lab Med ; EmRisch et al. Serum cystatin C is superior to serum creatinine as a marker of kidney function: Cystatin C as a renal function estimator in advanced chronic renal failure stages.

A more accurate method to estimate glomerular filtration rate from serum creatinine: Cystatin C is not more sensitive than creatinine for detecting early renal impairment in patients with diabetes.

Recruited patients were cisstatina into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. J Am Soc Nephrol ; It is reabsorbed totally and catabolised in the proximal tubules.

Early effects of methylprednisolone infusion on serum cystatin C in patients with severe Graves’ophthalmopathy. Metab Syndr Relat Disord. Services on Demand Journal. To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior. Microalbuminuriauria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study.

J Am Soc Nephrol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License. Curr Opin Crit Care.

Are you a health professional able to prescribe or dispense drugs? Serum cystatin C is a more sensitive marker of glomerular function than fistatina creatinine.

Scand J Clin Lab Invest ; How to estimate GFR-serum creatinine, serum cystatin C or equations? Cystatin C showed a significant and positive correlation with age, duration of diabetes, and serum uric acid in group 2 for age: When we consider the relation between serum cystatin C and serum creatinine levels and MDRD in whole study population we determined that the predictive ability of serum creatinine for GFR was higher.

Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes. J Endocrinol Cistatnia ; Oxford Regional Prospective Study Group.

Determination of the production rate and non-renal clearance of cystatin C and estimation of the glomerular filtration rate from the serum concentration of cystatin C in humans. Bienvenido a siicsalud Contacto Inquietudes.

Changes in dietary protein intake has cistatinaa effect on serum cystatin C levels independent of the glomerular filtration rate. Evaluation of plasma cystatin C as a marker for glomerular filtration rate in patients with type 2 diabetes. Estimated GFR was calculated with 6 variable MDRD equation using age, race, gender, serum creatinine, blood urea nitrogen and albumin values.

Clin Nephrol ; All participants were included in the study after signing informed consent forms. As pursuant to our study, two studies show that cystatin C is not more sensitive than creatinine. Human cystatin C – Role of the N-terminal segment in the inhibition of human cysteine cisttatina and in its inactivation by leucocyte elastase. In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates.

A comparison of GFR estimating formulae based upon s-cystatin C and s-creatinine and a combination of the two. O gene que codifica a cistatina C foi sequenciado e localiza-se no cromossomo SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact.

Serum creatinine concentration is an imperfect measure of GFR. Conclusion Although urinary albumin excretion is suggested for detection of type 2 diabetic nephropathy, there is group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy.


Key words Cystatin C, glomerular function, cancer patients, cardiovascular risk, drug elimination. The third, diabetic foot ulcer with or without concomitant peripheral arterial disease is considered as two separate disease.

Course of glomerular filtration rate markers in patients receiving high-dose glucocorticoids following subarachnoidal hemorrhage. Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate.

Kruskal-Wallis test was used in intergroup comparison of the parameters not showing normal distribution and Mann-Whitney U test was used in the group causing the difference.

Serum cystatin C is superior to serum creatinine as a marker of kidney function: Cystatin C as a marker of GFR-history, indications, and future research.


Published studies are primarily clinical and epidemiological research but also basic. Am J Kidney Dis. Comparison of cystatin C, creatinine and creatinine clearance vs. Cystatin C is an endogenic marker used for GFR determination because its serum level is dependent to almost whole of eGFR particularly it is seen more valuable in normal and mild decreased eGFR.

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